IC 100: ASC Inhibitor

Overview

IC 100 is a monoclonal antibody that uniquely inhibits the adaptor ASC component of multiple inflammasomes, providing potential to treat a broad group of inflammatory disorders.

IC 100 inhibits ASC, blocking inflammasome formation, activation, and initiation of the inflammatory response.

IC 100 also inhibits the ASC component of ASC Specks, disrupting their structure and function, thereby preventing perpetuation of the massive inflammatory response.

By inhibiting both initiation and perpetuation of inflammation, IC 100 is expected to be effective for both stopping existing inflammation and preventing more inflammation from occurring in patients with inflammatory diseases.

IC 100 Blocks Inflammasome Formation
ASC Inhibitor

IC 100 Disrupts ASC Speck Structure and Function

Preclinical data summarized below demonstrate that IC 100 blocks the inflammatory cascade, as reflected by inhibition of both caspase-1 and IL-β.

ASC Inhibitor

  • THP-1 cell lysates were made at 4oC and the inflammasome was activated upon incubation at 30oC over a 1 hour period, resulting in caspase-1 cleavage
  • A serial dilution of IC 100 was added at the start of incubation at 37oC and blocked inflammasome activation as shown by preventing cleavage of caspase-1.

Cell Based Assay

  • IC 100 was incubated with THP-1 cells activated by inflammasome inducers, LPS and ATP
  • Intracellular inflammasome activation and release of IL-1β into the medium were inhibited

Data below demonstrate IC 100 has lower immunogenicity (9%) than many biologics used to treat inflammatory diseases, suggesting IC 100 has less potential for acquired drug resistance.

IC 100 Scientific Support

IC 100 has strong pre-clinical data related to multiple indications, as summarized below.

asc inhibitor

asc inhibitor