ASC Biomarker

Biomarkers are valuable tools to predict, diagnose, and monitor disease progression. They can also be used to target patients who are likely to respond to specific treatments, and to monitor ongoing efficacy of those treatments over time.

Researchers at the University of Miami evaluated serum inflammasome proteins as potential biomarkers for inflammatory disorders and identified ASC as a strong candidate1.  Serum ASC levels were elevated in patients with various inflammatory disorders when compared to healthy people.  Additionally, when compared to caspase-1 as a biomarker in patients with multiple sclerosis, ASC had a similar sensitivity to caspase-1, but a significantly higher specificity than caspase-1.

ASC BiomarkerASC Biomarker

References

  1. Keane RW, Dietrich DW, de Rivero Vaccari JP. Inflammasome Proteins as Biomarkers of Multiple Sclerosis. Frontiers in Neurology. Multiple Sclerosis and Neuroimmunology. 2018 Mar 19;9:135